Bulk CD34+ Cells from PLX Mobilized Leukopaks CellsExpress
CD34+ hematopoietic stem and progenitor cells isolated from PLX mobilized leukopaks. Bulk processing up to 2 x 10e10 TNC with ≥80% post thaw viability for specialized stem cell research applications.
Since our founding in 2010, CGT Global has pursued our mission to transform healthcare as we accelerate cell and gene therapy research and clinical trials, streamline the commercialization of new treatments, and map the last mile to patient access to these life-changing remedies. By innovating each stage in the cycle; development, commercialization, and delivery, we reduce the overall cost of the care and multiply access points so that millions can receive cutting edge, life-saving gene and cell therapies.
Description
CD34+ hematopoietic stem and progenitor cells isolated from PLX mobilized leukopaks support specialized stem cell and gene therapy research applications where alternative mobilization strategies are required.
CellsExpress offers bulk CD34+ isolation from PLX mobilized leukopaks, processing up to 2 x 10e10 total nucleated cells per collection to maximize stem and progenitor cell recovery while eliminating in house isolation variability.
PLX only mobilization is available for programs that specifically require this regimen. However, due to longer mobilization timelines compared to GCSF or GCSF + PLX strategies, PLX only collections are generally not recommended unless scientifically justified.
Important Consideration
PLX only mobilization may require extended donor scheduling timelines. For programs prioritizing speed and efficiency, GCSF or GCSF + PLX mobilization strategies are typically preferred.
Our team can help determine the optimal mobilization approach based on your program requirements.
Key Features
• CD34+ cells isolated from PLX mobilized leukopaks
• Up to 2 x 10e10 total nucleated cells processed
• High purity CD34+ enrichment
• ≥80% post thaw viability
• Cryopreserved and ready for immediate downstream use
• Custom vial sizing available
• HLA typing and recallable donors available
Ideal Applications
• Specialized stem cell therapy research
• Programs requiring specific mobilization regimens
• Gene editing workflows
• Stem cell expansion and differentiation studies
• Translational research applications
Additional information
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Product Information Sheet
Mobilized Peripheral Blood
Selected publications demonstrating the use of mobilized peripheral blood and mobilized leukopak-derived CD34+ hematopoietic stem and progenitor cells in gene therapy, cell therapy, and transplantation workflows.
Hematopoietic reconstitution dynamics of mobilized peripheral blood-derived stem cells after gene therapy
Nature Communications · 2023
Mobilized peripheral blood-derived hematopoietic stem and progenitor cells were used for gene therapy, showing improved engraftment and recovery compared to traditional sources.
Mobilized Blood · HSPC · Gene Therapy
In vivo CRISPR gene editing in hematopoietic stem cells
Nature Biotechnology · 2022
Mobilized CD34+ hematopoietic stem cells were used in gene editing workflows to evaluate therapeutic genome engineering strategies.
CD34+ Cells · CRISPR · Gene Editing
Ex vivo expansion and functional characterization of hematopoietic stem cells
Stem Cell Research · 2023
Mobilized peripheral blood-derived hematopoietic stem cells were expanded ex vivo and evaluated for functional and therapeutic potential.
HSPC · Expansion · Stem Cell Biology
Optimized lentiviral production and transduction of primary human cells
Molecular Therapy Methods & Clinical Development · 2024
Mobilized CD34+ cells and primary immune cells were transduced using optimized viral production systems for gene and cell therapy applications.
CD34+ Cells · Viral Transduction
Improved workflows for gene modification in hematopoietic stem cells
Molecular Therapy Methods & Clinical Development · 2024
Mobilized hematopoietic stem cells were used to evaluate improved gene modification and cell engineering workflows.
Gene Editing · HSPC
Mobilized peripheral blood stem cells in transplantation and hematologic recovery
Blood · 2023
Mobilized peripheral blood stem cells were used in transplantation workflows to evaluate hematologic recovery and clinical outcomes.
Transplantation · Mobilized Blood
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