Cord Blood CD133+ Stem/Progenitor Cells, Pooled Donors, Frozen
Human CD133 is a transmembrane glycoprotein that is expressed on CD34+ and CD34– multipotent stem and progenitor cells that are involved in hematopoiesis. Unlike CD34+ cells, cord blood CD133+ cells are also expressed on circulating endothelial precursors that are involved in vasculogenesis. Additionally, cord blood CD133+ hematopoietic cells have been found to differentiate in vitro to cells of the ectodermal and mesodermal lineages implying that these cells have the ability to give rise to cells of non-hematopoietic lineages.
Human cord blood CD133+ stem and progenitor cells are positively selected using immunomagnetic anti-CD133 (clone AC133) microbeads from the mononuclear cell fraction. Pooled CD133+ cells are from two or more donors and are available in larger lots. Isolated cells are characterized by flow cytometry prior to cryopreservation to ensure a highly pure and viable cell population.
Cord blood is collected from mothers that are negative for HIV, HepB, and HepC during pregnancy. Testing on cord blood can be provided as a custom order.
Cells were obtained using Institutional Review Board (IRB) approved consent forms and protocols.
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