Introduction
CD34+ cells are the foundation of regenerative medicine and immunotherapy research. These hematopoietic stem and progenitor cells (HSPCs) are used in applications ranging from CAR-T and NK cell manufacturing to gene editing and transplant modeling.
In 2026, researchers can source CD34+ cells from several isolation routes — each with its own yield, viability, and cost profile:
- Mobilized Peripheral Blood (using G-CSF or plerixafor)
- Cord Blood
- Bone Marrow
- Leukopak-derived or PBMC-isolated fractions
This guide compares the top CD34+ suppliers by purity, isolation method, availability, and transparency, helping you select the right fit for your research program.
How CD34+ Cells Are Isolated
Each source type offers distinct advantages depending on your downstream use case.
| Source | Typical Yield | Key Advantages | Considerations |
|---|---|---|---|
| Mobilized Peripheral Blood | High (≥1×10⁶ CD34+ per mL) | Rapid collection, scalable, higher CD34+ fraction | Requires donor mobilization (G-CSF or plerixafor) |
| Cord Blood | Moderate | Naive HSPCs, high stemness, less exposure to antigens | Lower total yield, single collection only |
| Bone Marrow | Variable | Classical source, well-established clinical history | Invasive donor process, limited scalability |
| Leukopak / PBMC Derived | Low–Moderate | Readily available, cost-effective | Requires enrichment and sorting |
At CGT Global, CD34+ enrichment is achieved using magnetic bead selection (MACS) and FACS sorting from mobilized leukopaks, cord blood, or peripheral blood, providing high-purity, research-use material across multiple donor types.
Top CD34+ Cell Suppliers for 2026
1. CGT Global
Best for: Flexible sourcing (mobilized, cord blood, or leukopak) and rapid delivery
CGT Global supplies CD34+ cells isolated from G-CSF or plerixafor-mobilized donors, cord blood, or non-mobilized leukopaks.
Each batch includes a Certificate of Analysis detailing purity, viability, and isolation method.
Highlights
- Purity ≥90% via MACS or FACS selection
- Multiple donor options: mobilized, cord blood, bone marrow-like phenotype
- 24–48-hour fulfillment for cryopreserved units
- Optional HLA, CMV, and donor demographics
- Responsive support via chat, phone, and email
Learn more about Leukopak sourcing and isolation and PBMC Viability and Recovery.
2. STEMCELL Technologies
Best for: Cord blood-derived CD34+ HSPCs
STEMCELL offers frozen cord blood CD34+ cells (catalog #70002) starting around $910 USD per vial, with bulk discounts. They also provide mobilized peripheral blood CD34+ cells at higher price points (~$1,300–$1,600 per vial).
3. AllCells
Best for: Mobilized and non-mobilized peripheral blood CD34+ cells
AllCells provides cryopreserved CD34+ cells isolated via MACS from G-CSF-mobilized donors. Custom HLA-typed donor selection is available. Prices are quote-based, typically in the $2,000–$4,000 range per vial.
4. iXCells Biotechnologies
Best for: Research-grade CD34+ cells at multiple scales
iXCells offers peripheral blood CD34+ cells at $1,671 (0.2 M cells) and $2,571 (0.5 M cells). Each unit is supplied with viability and purity data, suitable for in-vitro research and assay validation.
5. HumanCells Bio
Best for: Cord blood CD34+ at entry-level pricing
HumanCells Bio lists cord blood CD34+ cells (0.75–1 M per vial) at around $1,750 USD. They focus on research-use-only material with COA documentation and rapid fulfillment.
6. Discovery Life Sciences
Best for: Data-rich mobilized CD34+ collections
Discovery Life Sciences offers mobilized leukopak-derived CD34+ cells with linked donor data (phenotyping and genotyping). Pricing and lead times are quote-only but targeted at translational research groups.
7. BioIVT
Best for: Custom donor CD34+ collections
BioIVT supports custom mobilization protocols and HLA-matched donor recruitment. Availability depends on collection schedules, with strong traceability and QC documentation.
8. Charles River Laboratories
Best for: IND-adjacent programs needing documentation depth
Through its HemaCare brand, Charles River offers mobilized CD34+ cells from GMP-aligned collections. While pricing is not public, it’s typically among the higher-end vendors for documentation-heavy projects.
Comparison Table
FAQs
What’s the difference between mobilized and cord blood CD34+ cells?
Mobilized cells yield more total CD34+ per collection, while cord blood CD34+ cells are more naive and ideal for early differentiation research.
Can CD34+ cells be isolated from leukopaks?
Yes. Using MACS or FACS, CD34+ enrichment from leukopaks is common. It provides flexibility and scalability for preclinical work.
How long can CD34+ cells remain viable after thawing?
Typically, 85–90% viability post-thaw with proper cryomedia and rapid thawing protocols.
Which source is best for my application?
- Mobilized PB: highest yields, scalable collections.
- Cord Blood: stemness and low immunogenicity.
- Bone Marrow: classical HSPC profile, used for comparison or validation.
Conclusion
Sourcing high-quality CD34+ cells depends on your downstream application and timeline. Mobilized and cord blood sources dominate 2026 offerings due to scalability and purity.
CGT Global remains a preferred partner for researchers seeking rapid access, flexible donor options, and high-purity CD34+ isolations from multiple validated sources.
Disclaimer
All product and pricing information in this article is derived from publicly available sources as of October 2025. Data such as purity, donor criteria, and availability are subject to change without notice.
This content is provided for research comparison and educational purposes only and does not imply endorsement or criticism of any supplier. All product names and trademarks belong to their respective owners.
Readers should verify details directly with vendors before making purchasing decisions.
