CGT Global Blog
CGT Global News
Stay ahead in the dynamic world of Accelerating Cell and Gene Therapy with the CGT Global blog and news page. Explore insightful articles, industry updates, product updates, and expert analysis on all things CGT Global. Stay informed, inspired, and connected with CGT Global – your go-to source for cutting-edge insights in the ever-evolving realm of research, clinical projects and healthcare.
CGT Sourcing Guide 2025: How to Build a Resilient Supply Chain Amid Tariff Pressures
By CGT Global The latest round of U.S. tariffs didn’t just shake up the headlines—it shook the very foundations of global pharma supply chains. And while most of the buzz has focused on traditional drugmakers, let’s be clear: cell and gene therapy manufacturers aren’t sitting this one out. For companies working with high-value, time-sensitive materials like Leukopaks, PBMCs, CD34+ cells, and viral vectors, even subtle disruptions can have massive downstream consequences. Now, with added costs, uncertain delivery timelines, and sourcing challenges entering…
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How Natural Killer Cells are Revolutionizing Cancer Treatment
By Joanna Wirkus What makes Natural Killer (NK) Cells the Perfect Weapon Against Cancer? Unlike the T cells of the adaptive immune system, innate natural killer (NK) cells protect the body against tumors without prior programming. They recognize and become activated by abnormal cells that lack or express key outer membrane markers characteristic of cancer. One way NK cells initiate malignant cell death is by unleashing granules of membrane penetrating perforins and caspase-activating, apoptosis-initiating granzymes. Their inherent anti-cancer abilities make NK cells…
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How to Improve Humanized Mouse Engraftment: CD34+ Cell Sourcing & Viability Tips
By: Joanna Wirkus Simple Steps to Significantly Improve Humanized Mice Engraftment Success Previously in “Overcoming Challenges with Animal Models in Research”, we covered why animal models with human immune systems have significantly improved the translation of preclinical findings into life-saving treatments. Successfully creating these advanced models for testing new therapies relies on high hematopoietic stem cell engraftment rates. By boosting engraftment rates, scientists can better model human diseases to advance drug development and immune system engineering. Low engraftment rates can lead to…
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Cord Blood CD34+ Cells: High Viability for Humanized Mouse Models
By: Joanna Wirkus The Rise of Cord Blood CD34+ Cells in Humanized Mouse Models and Cell Therapy Innovation Scientists in the late 1980’s discovered that umbilical cord blood derived stem cells had high proliferative potential and tolerated cryopreservation and thawing (Broxmeyer, 1989). Building on this research, the first report of cord blood derived CD34+ human stem cells successfully engrafting and restarting hematopoiesis in immunodeficient mice was published in 1997 (Hogan, 1997). Placenta and umbilical cords were previously discarded as medical waste. Today,…
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Cryopreservation in Cell and Gene Therapy: Ensuring High-Viability Cells for Research & Manufacturing
By Joanna Wirkus The Role of Cryopreservation in Cell and Gene Therapy Cryopreservation is a cornerstone of cell and gene therapy, enabling the long-term storage and viability of vital cell types such as CD34+ hematopoietic stem cells, mesenchymal stem cells (MSCs), natural killer (NK) cells, and T cells used in CAR-T therapies. Interestingly, nature has its own version of cryopreservation: the North American wood frog survives winter by producing natural cryoprotectants like glucose and urea-no liquid nitrogen required. How Cryopreservation Works Water’s…
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CellsExpress: Affordable, Bulk Isolated Bone Marrow-Derived Stem Cells That Accelerate Your Cell and Gene Therapy Research
By Joanna Wirkus Bulk Bone Marrow Stem Cells for Research | CGT Global The race to develop life-saving cell and gene therapies is intensifying. Amid shifting political pressures, uncertain funding landscapes, and rising inflation, scientists are being asked to do more with less. Time, money, and labor must be optimized at every step—and that starts with securing a consistent, cost-effective source of stem cells. For researchers working with bone marrow-derived stem cells, sourcing high-quality material can drain time and resources. That’s where CellsExpress from CGT…
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Optimizing Gene and Cell Therapy Research by Starting with Properly Sourced Human Bone Marrow Cells
By: Joanna Wirkus Bone Marrow Cells: Critical Tools Driving Stem Cell and Gene Therapy Innovation Surprisingly safe and well tolerated, the first bone marrow biopsy was performed on the shinbone in 1908 by Italian physician Giovanni Ghedini. Today, bone marrow continues to be an important source of information about the health status of individuals with bone marrow disorders and a gold mine for new discoveries in stem cell science to benefit society. By studying bone marrow cells, scientists can unlock important, life-saving…
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Gene Therapy Research: Past, Present, Future
Gene Therapy Research: Past, Present, Future By: Joanna Wirkus Gene Therapy: Where We’ve Been: The Human Genome Project concluded in 2003 after 13 years of effort aimed at mapping the entire Human Genome and improving DNA sequencing technology at large. This milestone set the foundation for a better understanding of the drivers of disease at the molecular level. Since then, scientists have been harnessing the power of genetics and genomics to revolutionize therapeutic approaches for the treatment of diseases. CGT Global…
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Cell Therapy Research: Past, Present, and Future
Cell Therapy Research: Past, Present, and Future By Joanna Wirkus The drive to understand the origins of disease has led us to investigate the basic unit of life, the cell. Historically, it was thought that demons, spells, or ‘bad air’ caused illness. Over three and a half centuries, science has advanced to better understand how cellular biology can be leveraged to treat disease. Now, modern medicine is revolutionizing the field of “Cell Therapy”. With cell therapy, biotechnologists can isolate healthy cells to…
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Overcoming Challenges with Animal Models in Research
Overcoming Challenges with Animal Models in Research – How Starting With the Right Cells Can Improve Science That Saves Lives BY JOANNA WIRKUS One estimate reports that more than 100 million mice are used in biomedical research each year in the U.S. Mus musculus, the most common model organism, has been the foundation of biological science since the early 1900s due to its convenient size, reproductive capability, and ease of care and handling. While mice and humans are ~85% genetically similar, many…
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CGT Global Attends Advanced Therapies USA 2024 to Support Cell and Gene Therapy Innovation
CGT Global’s Cate Spears and Eliona Kola attend Advanced Therapies USA 2024, engaging with industry leaders to advance cell and gene therapy innovation. Attending Advanced Therapies USA is a valuable opportunity to engage with global leaders and drive innovation in cell and gene therapy.”— Cate Spears, CEO of CGT Global, FOLSOM, CA, UNITED STATES, November 12, 2024 /EINPresswire.com/ — CEO Cate Spears and Process Development Scientist Eliona Kola to Attend Premier Industry Event CGT Global, a leader in cell and gene therapy…
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EIN Presswire: CGT Global Receives Approval Aiding Scientists in Discovering Life-Saving Cures
CGT Global, a leading Contract Research Organization (CRO) & biotech manufacturer announced approval to provide disease state leukopaks to researchers worldwide FOLSOM, CALIFORNIA, UNITED STATES, June 11, 2024 /EINPresswire.com/ — CGT Global, a leading international Contract Research Organization (CRO) and biotech manufacturer, announced today it has received approval from Western Copernus Group (WCG) to provide disease state leukopaks to researchers in the US and worldwide. WCG is an independent Institutional Review Board (IRB) made up of 200 experts that are augmented by one of the…
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