Peripheral Blood CD4+CD45RA+ Naïve Helper T Cells, Frozen

Human peripheral blood CD4+CD45RA+ naïve helper T cells are enriched by depleting cells expressing CD8, CD14, CD15, CD16, CD19, CD25, CD34, CD36, CD56, CD123, CD45RO, TCRγ/δ, anti-HLA-DR, and CD235a from the mononuclear cell population using immunomagnetic particles leaving purified, untouched CD4+CD45RA+ naïve helper T cells. Isolated cells are characterized by flow cytometry before cryopreservation to ensure a highly pure and viable cell population.

Cells were obtained using Institutional Review Board (IRB) approved consent forms and protocols.

Since our founding in 2010, CGT Global has pursued our mission to transform healthcare as we accelerate cell and gene therapy research and clinical trials, streamline the commercialization of new treatments, and map the last mile to patient access to these life-changing remedies.  By innovating each stage in the cycle; development, commercialization, and delivery, we reduce the overall cost of the care and multiply access points so that millions can receive cutting edge, life-saving gene and cell therapies.

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Description

Naïve helper T cells are mature T cells that have left the thymus and have yet to be exposed to an antigen presented by MHC class II molecules of an antigen-presenting cell (APC). In humans, CD4+ naïve helper T cells are constantly recirculating into the secondary lymphoid tissues in order to optimize the opportunity of finding their specific antigen.

Additional information

Anticoagulant

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Figure 1. Representative flow data of the enriched CD4+CD45RA+ cells (91.0%) from peripheral blood prior to cryopreservation.