CGT Global Blog
CGT Global News
Stay ahead in the dynamic world of Accelerating Cell and Gene Therapy with the CGT Global blog and news page. Explore insightful articles, industry updates, product updates, and expert analysis on all things CGT Global. Stay informed, inspired, and connected with CGT Global – your go-to source for cutting-edge insights in the ever-evolving realm of research, clinical projects and healthcare.
CGT Global Folsom Celebrates One Year Anniversary
It’s been one year since StemExpress moved our laboratory headquarters from Placerville to Folsom, CA. Our new state-of-the-art facility has enabled us to increase production and meet the growing needs of our clients. We thank our dedicated staff, the community of Folsom, and our clients for making the past year a successful one.
Read MoreDirected differentiation of human bone marrow MSCs to functional Schwann cells
The peripheral nervous system (PNS) comprises many complex cell types that work together to transmit electrical signals from the body’s sensory receptors to the central nervous system (CNS) and vice versa. Peripheral nerve cells relay the electrical signals through the long, thin part of the cell called an axon. Schwann cells create nodes of myelin sheath around the axon called nodes of Ranvier. Between each node is a break essential for increasing the speed of which the electrical signal travels between distant…
Read MoreTreating the side effects of chemotherapy
The human body has many lines of defense against infection, keeping us healthy and free of disease. One immediate line of defense is the innate immune system, which is comprised of white blood cells that are ready to fight against bacterial or fungal infection at birth. One of the most numerous and important cells of the innate immune system is phagocytic granulocytes or neutrophils. These cells spend most of their lives circulating in the peripheral blood, but once stimulated by a sequence…
Read MoreHow CAR-T cell therapy works
On August 30, 2017, the FDA approved the first US CAR-T cell therapy for the treatment of ALL patients. According to FDA Commissioner Dr. Scott Gottlieb, “We’re entering a new frontier in medical innovation with the ability to reprogram a patient’s own cells to attack a deadly cancer.” Check out this brief video about how CAR-T cell therapy works. At StemExpress we offer human blood products such as whole blood and Leukopaks as well as peripheral blood CD3+, CD4+, and CD8+ T cells. Purified primary CD3+, CD4+, and…
Read MoreMake finding the right human biospecimen easy!
Remove the waiting and the endless paperwork that comes with collecting human biospecimens. With StemExpress’ robust donor pool, we make finding the right donor for your research a simple and straightforward process. StemExpress has partnered with iSpecimen Marketplace to enhance that connection via a straightforward online resource. Through this partnership, StemExpress enhances its capabilities to reach scientists that require a diverse selection of human samples ranging from frozen tumors to blood samples. StemExpress and iSpecimen Marketplace are working together to bring you…
Read MoreA New Approach to Treating Myelodysplastic Syndrome
Myelodysplastic syndrome (MDS) is a group of bone marrow disorders where the bone marrow is incapable of producing healthy mature blood cells. Through a process called hematopoiesis, blood stem cells or hematopoietic stem and progenitor cells (HSPC) within the bone marrow give rise to blood cells, such as white blood cells, platelets, and red blood cells. In an individual with MDS the HSPCs fail to mature and either die in the bone marrow or soon after they enter the bloodstream. The lack…
Read MoreIntegration of Large Transgenes into the Genome of Hematopoietic Primary Cells
RNA-guided CRISPR-Cas9 nuclease is a genome-editing tool that allows researchers to edit parts of the genome by removing, adding, or altering sections of the DNA sequence. CRISPR-Cas9 targets double-stranded DNA using single guided RNA (sgRNA) that shepherds the nuclease to the target DNA sequence. Once at the target, CRISPR-Cas9 creates a double-stranded DNA break. Consequently, the hosts own DNA repair mechanisms, such as non-homologous end-joining (NHEJ) or homology-directed repair (HDR), repairs the break. To alter or correct a dysfunctional gene CRISPR-Cas9 nuclease…
Read MoreImportant Oversight on Human Germline Genome Editing
In light of the recent article published in Nature, human germline genome editing in the US has taken a front and center stage in the ethical principles and scientific boundaries of modern science. Researchers at the Oregon Health and Science University (OHSU) in Portland, led by reproductive biologist Shoukhrat Mitalipov, corrected a gene mutation responsible for the thickening of the heart muscle in viable human embryos using CRISPR-Cas9 gene editing. Targeting a dominant mutation that leads to heart failure, the researchers obtained…
Read MoreCGT Global Signs Distribution Agreement with CliniSciences
StemExpress is a premier provider of human blood-derived cell products, including bone marrow, cord blood, peripheral blood, Leukopaks and Mobilized Leukopaks. To continue meeting the needs of clients abroad, StemExpress has expanded its global capabilities to Europe through a distribution agreement with CliniSciences, a supplier of research and in-vitro diagnostic products, that pride themselves in delivering adaptability, flexibility, and reactivity to their customers. This partnership ensures that researchers in Europe have access to StemExpress’ high-quality fresh and cryopreserved hematopoietic products with easily…
Read MoreHumanized Mice for HIV Research
According to the World Health Organization (WHO), approximately 36.7 million people are living with HIV and one million have died due to a failing immune system in 20161. Currently, antiretroviral treatment therapy is used to prevent disease progression, but a cure has perplexed scientist for over 40 years. To find a cure, improvements in the understanding of the pathogenesis of HIV infection need to be made. Animal modeling has greatly enhanced our ability to understand the human immune system and the diseases…
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