Cord Blood CD34+ Stem/Progenitor Cells, Single Donor, Frozen
CD34 is a glycosylated transmembrane protein and represents a well-established marker for human hematopoietic stem and progenitor cells in peripheral blood, bone marrow, and cord blood. CD34+ cells are self-renewing, multipotent stem cells that give rise to all blood cells of the immune system through a process called hematopoiesis. As hematopoietic stem cells progress through hematopoiesis they generate the myeloid (monocytes, macrophages, granulocytes, megakaryocytes, dendritic cells, erythrocytes) and lymphoid (T cells, B cells, NK cells) lineages. The highly specialized cells that arise from hematopoietic stem cells work collaboratively in defending the body against infection and disease.
Human cord blood CD34+ stem and progenitor cells are positively selected using immunomagnetic anti-CD34 (clone QBEND10) microbeads from the mononuclear cell fraction. Isolated cells are characterized by flow cytometry prior to cryopreservation to ensure a highly pure and viable cell population.
Cells were obtained using Institutional Review Board (IRB) approved consent forms and protocols.
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Halkias et al. (2015) Conserved and Divergent Aspects of Human T-cell Development and Migration in Humanized Mice. Immunol Cell Biol 1-11. doi:10.1038/icb.2015.38.
Cleyrat et al. (2017) Gene Editing Rescue of a Novel MPL Mutant Associated with Congenital Amegakaryocytic Thrombocytopenia. Blood Advances 1: 1815-1826. doi.org/10.1182/bloodadvances.201600291.
Takahashi et al. (2018) Enhanced Antibody Responses in a Novel NOG Transgenic Mouse with Restored Lymph Node Organogenesis. Front. Immunol 1(17). doi.org/10.3389/fimmu.2017.02017.
Ito et al. (2020) Bovine β-Lactoglobulin-Induced Passive Systemic Anaphylaxis Model Using Humanized NOG hIL-3/hGM-CSF Transgenic Mice. Int Immunol. DOI: 10.1093/intimm/dxaa067.